Significance of Persistent Systemic Support in the Clinical Course of Delayed Post-hypoxic Leukoencephalopathy Following Severe Coronavirus Disease 2019
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- Kawasaki Juri
- Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
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- Mato Naoko
- Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
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- Fujii Hiroyuki
- Department of Radiology, Jichi Medical University, Japan
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- Miura Kumiko
- Division of Neurology, Department of Medicine, Jichi Medical University, Japan
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- Mashiko Takafumi
- Division of Neurology, Department of Medicine, Jichi Medical University, Japan
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- Katayama Shinshu
- Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University, Japan
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- Yamanouchi Yoshitaka
- Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
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- Sato Miki
- Postgraduate Clinical Training Center, Jichi Medical University Hospital, Japan
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- Takasaki Toshikazu
- Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
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- Takigami Ayako
- Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
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- Hisata Shu
- Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
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- Nunomiya Shin
- Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University, Japan
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- Hagiwara Koichi
- Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
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- Maemondo Makoto
- Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
抄録
<p>A 45-year-old woman was hospitalized with severe coronavirus disease 2019 pneumonia. Following cytokine storm-induced multiorgan failure and lethal arrhythmia, the patient developed a sustained coma with flaccid quadriplegia. A cerebrospinal fluid examination excluded infectious and immunogenic encephalopathies, and diffusion-weighted magnetic resonance imaging demonstrated high-intensity areas in the white matter with a cortex-sparing distribution, suggesting delayed post-hypoxic leukoencephalopathy. As a result of intensive cardiopulmonary support for a month, the neurological function gradually recovered. Based on the reversible clinical course noted in this patient, accurate diagnosis and persistent medical approaches are important for the management of coronavirus disease 2019-related delayed post-hypoxic leukoencephalopathy. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 63 (8), 1167-1172, 2024-04-15
一般社団法人 日本内科学会