Significance of Persistent Systemic Support in the Clinical Course of Delayed Post-hypoxic Leukoencephalopathy Following Severe Coronavirus Disease 2019

  • Kawasaki Juri
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
  • Mato Naoko
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
  • Fujii Hiroyuki
    Department of Radiology, Jichi Medical University, Japan
  • Miura Kumiko
    Division of Neurology, Department of Medicine, Jichi Medical University, Japan
  • Mashiko Takafumi
    Division of Neurology, Department of Medicine, Jichi Medical University, Japan
  • Katayama Shinshu
    Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University, Japan
  • Yamanouchi Yoshitaka
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
  • Sato Miki
    Postgraduate Clinical Training Center, Jichi Medical University Hospital, Japan
  • Takasaki Toshikazu
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
  • Takigami Ayako
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
  • Hisata Shu
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
  • Nunomiya Shin
    Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University, Japan
  • Hagiwara Koichi
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan
  • Maemondo Makoto
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan

抄録

<p>A 45-year-old woman was hospitalized with severe coronavirus disease 2019 pneumonia. Following cytokine storm-induced multiorgan failure and lethal arrhythmia, the patient developed a sustained coma with flaccid quadriplegia. A cerebrospinal fluid examination excluded infectious and immunogenic encephalopathies, and diffusion-weighted magnetic resonance imaging demonstrated high-intensity areas in the white matter with a cortex-sparing distribution, suggesting delayed post-hypoxic leukoencephalopathy. As a result of intensive cardiopulmonary support for a month, the neurological function gradually recovered. Based on the reversible clinical course noted in this patient, accurate diagnosis and persistent medical approaches are important for the management of coronavirus disease 2019-related delayed post-hypoxic leukoencephalopathy. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 63 (8), 1167-1172, 2024-04-15

    一般社団法人 日本内科学会

参考文献 (22)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ