Drug-induced Interstitial Nephritis in a Patient with Ulcerative Colitis Treated with 5-Aminosalicylic Acid
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- Hayashi Daichi
- Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
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- Nishida Tsutomu
- Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
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- Osugi Naoto
- Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
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- Kusunoki Yasuo
- Division of Nephrology, Department of Internal Medicine, Toyonaka Municipal Hospital, Japan
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- Okabe Satoru
- Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
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- Fujii Yoshifumi
- Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
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- Nakamatsu Dai
- Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
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- Matsumoto Kengo
- Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
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- Yamamoto Masashi
- Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
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- Fukui Koji
- Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
Abstract
<p>This report describes the case of a 76-year-old man with ulcerative colitis who developed interstitial nephritis after starting 5-Aminosalicylic acid (5-ASA) therapy. The patient experienced an initial improvement in symptoms, but developed fatigue, anorexia, and severe renal dysfunction 2.5 months later. Renal biopsy confirmed drug-induced interstitial nephritis, and conservative treatment with fluid replacement and the discontinuation of 5-ASA improved the patient's condition. Clinicians should monitor patients receiving 5-ASA therapy for potential adverse effects, particularly renal injury, and promptly investigate symptoms of renal dysfunction. Early recognition and discontinuation of the offending agent may prevent further damage and improve patient outcomes. </p>
Journal
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- Internal Medicine
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Internal Medicine 63 (8), 1081-1085, 2024-04-15
The Japanese Society of Internal Medicine