Cellular and molecular insights into the individual difference in COVID-19 mRNA vaccine responses
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- ISHIKAWA Hiroki
- Immune Signal Unit, Okinawa Institute of Science and Technology, Graduate University (OIST), 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa 904-0495, Japan
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- HIROTA Masato
- Immune Signal Unit, Okinawa Institute of Science and Technology, Graduate University (OIST), 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa 904-0495, Japan
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- TAMAI Miho
- Immune Signal Unit, Okinawa Institute of Science and Technology, Graduate University (OIST), 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa 904-0495, Japan
抄録
<p>The effectiveness of vaccines in preventing infection from specific pathogens is closely related to the magnitude of the antigen-specific T cell and antibody responses induced by the vaccine. These responses depend on the immune states of the individual, which is shaped by genetic and environmental factors. Recent studies using omics technologies identified immune cells, genes, and gut microbial species and metabolic pathways at baseline or during early vaccine responses as correlates of vaccine responses. These findings shed light on the molecular and cellular mechanisms underlying the inter-individual differences in vaccine responses. In this review, we provide an overview of correlates of recently developed COVID-19 mRNA vaccine-induced adaptive immune responses.</p>
収録刊行物
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- Translational and Regulatory Sciences
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Translational and Regulatory Sciences 6 (1), 15-19, 2024
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詳細情報 詳細情報について
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- CRID
- 1390862853908349440
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- ISSN
- 24344974
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可