Severe Cytokine Release Syndrome and Immune Effector Cell-associated Neurotoxicity Syndrome in a Man Receiving Immune Checkpoint Inhibitors for Lung Cancer
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- Tanaka Takaaki
- Department of Respiratory Medicine, Okayama University Hospital, Japan
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- Taoka Masataka
- Department of Respiratory Medicine, Okayama University Hospital, Japan
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- Makimoto Go
- Department of Respiratory Medicine, Okayama University Hospital, Japan Center for Clinical Oncology, Okayama University Hospital, Japan
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- Ninomiya Kiichiro
- Center for Comprehensive Genomic Medicine, Okayama University Hospital, Japan
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- Higo Hisao
- Department of Respiratory Medicine, Okayama University Hospital, Japan
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- Fujii Masanori
- Department of Respiratory Medicine, Okayama University Hospital, Japan
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- Ichihara Eiki
- Department of Respiratory Medicine, Okayama University Hospital, Japan
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- Ohashi Kadoaki
- Department of Respiratory Medicine, Okayama University Hospital, Japan
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- Hotta Katsuyuki
- Center for Innovative Clinical Medicine, Okayama University Hospital, Japan
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- Tabata Masahiro
- Center for Clinical Oncology, Okayama University Hospital, Japan
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- Maeda Yoshinobu
- Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
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Abstract
<p>A 55-year-old man with stage IV lung adenocarcinoma was treated with cisplatin, pemetrexed, nivolumab, and ipilimumab. Approximately 100 days after treatment initiation, he became disoriented and presented to the emergency department with a high fever. Blood tests revealed liver and kidney dysfunctions. Subsequently, the patient developed generalized convulsions that required intensive care. He was clinically diagnosed with cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Organ damage was gradually controlled with immunosuppressive drugs, including steroids, and the patient was discharged. Successful treatment is rare in patients with CRS, including ICANS, during immune checkpoint inhibitor treatment for solid tumors. </p>
Journal
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- Internal Medicine
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Internal Medicine 63 (9), 1261-1267, 2024-05-01
The Japanese Society of Internal Medicine
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Keywords
Details 詳細情報について
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- CRID
- 1390862943886022912
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- NII Book ID
- AA10827774
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- ISSN
- 13497235
- 09182918
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- PubMed
- 37722894
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- Crossref
- PubMed
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- Abstract License Flag
- Disallowed