低周波磁界ばく露による神経スフェロイド内電界分布の推定

DOI Web Site
  • 齋藤 淳史
    （一財）電力中央研究所 サステナブルシステム研究本部 生物・環境化学研究部門
  • 椎名 健雄
    （一財）電力中央研究所 グリッドイノベーション研究本部 ファシリティ技術研究部門
  • 関場 陽一
    （株）電力計算センター 解析技術室 系統解析部

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  • Estimation of Electric Field Inside a Neural Spheroid by Low-Frequency Magnetic Field Exposure

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<p>Exposure to time-varying, low-frequency and high-intensity magnetic field (MF) induce electric field (EF) inside the human body, producing stimulus effects such as nerve fiber excitation or synaptic modulation. To measure such stimulus effects by low-frequency MF expsoure in real-time, we developed a fluorescent recording system using optical fibers that is neither affected by the MF nor affects the MF distribution. In this study, a numerical calculation model composed of voxels with a 6.25 µm spatial resolution was developed. Using this numerical model, we evaluated the distribution of the EF generated inside three-dimensional neuronal tissue called neural spheroid, under 50 Hz sinusoidal wave, 300 mT (root mean square) uniform MF exposure. We also investigated the influence of the optical fiber on the electric field distribution in neural spheroid. As a result, MF produced an induced EF in the neural spheroid of more than 4 V/m, well above the theoretical threshold of synaptic modulation. These results indicated that our experimental system was suitable for the evaluation of the threshold of stimulus effects using neural spheroid.</p>

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