New Developments and Possibilities in Mechanochemical Organic Syntheis

DOI
  • Ito Hajime
    Institute for Chemical Reaction Design and Discovery, Hokkaido University Faculty of Engineering, Hokkaido University

Bibliographic Information

Other Title
  • メカノケミカル有機合成の新展開と可能性

Abstract

Unlike conventional organic synthesis, mechanochemical organic synthesis uses a grinding machine such as a ball mill as a reaction vessel. This method has the advantages of greatly reducing the reaction solvent, increasing the reaction rate, simplifying the operation, and enabling reactions of poorly soluble compounds. In the past five years, we have demonstrated the usefulness of mechanochemical organic synthesis by developing palladium-catalyzed cross-coupling reactions, reactions of poorly soluble chemicals, synthesis of organometallic compounds such as Grignard reagents, fast Birch reduction, and mechanoredox reactions using piezoelectric materials. The results showed the usefulness of mechanochemical organic synthesis.

Journal

  • MEDCHEM NEWS

    MEDCHEM NEWS 34 (2), 97-102, 2024-05-01

    The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

  • CRID
    1390862943886464256
  • DOI
    10.14894/medchem.34.2_97
  • ISSN
    24328626
    24328618
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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