Antimicrobial resistance patterns of <i>Streptococcus uberis</i> isolates from bovine milk in Chiba prefecture, Japan: association between multidrug resistance and clonal complex 996

DOI Web Site PubMed 参考文献20件
  • TSUYUKI Yuzo
    Division of Clinical Laboratory, Sanritsu Zelkova Veterinary Laboratory, Tokyo, Japan Laboratory of Infectious Diseases, Graduate School of Infection Control Sciences & Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan Matsuoka Research Institute for Science, Tokyo, Japan
  • MAEDA Takahiro
    Laboratory of Infectious Diseases, Graduate School of Infection Control Sciences & Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan
  • TORII Kae
    Division of Clinical Laboratory, Sanritsu Zelkova Veterinary Laboratory, Tokyo, Japan
  • YOSHIDA Haruno
    Laboratory of Infectious Diseases, Graduate School of Infection Control Sciences & Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan
  • IKEDA Noriaki
    Division of Clinical Laboratory, Obihiro Clinical Laboratory, Hokkaido, Japan
  • YOSHIDA Saki
    Division of Clinical Laboratory, Obihiro Clinical Laboratory, Hokkaido, Japan
  • ITO Masahiko
    Division of Clinical Laboratory, Sapporo Clinical Laboratory, Hokkaido, Japan
  • GOTO Mieko
    Laboratory of Infectious Diseases, Graduate School of Infection Control Sciences & Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan
  • TAKAHASHI Takashi
    Laboratory of Infectious Diseases, Graduate School of Infection Control Sciences & Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan

抄録

<p>Streptococcus uberis is one of major pathogens causing bovine mastitis. However, there is poor information on antimicrobial resistance (AMR) among the Japanese isolates. To provide treatment information for the mastitis caused by S. uberis in Japan, we aimed to clarify AMR patterns of the isolates from bovine milk mainly in Chiba. AMR phenotyping/genotyping [blaZ–erm(A)–erm(B)–mef(A)–linB–lnuD–tet(M)–tet(O)–tet(K)–tet(L)–tet(S)] and multilocus sequence typing were performed to analyze relationships between AMR patterns and clonal complexes (CCs). Resistance to tetracycline-, macrolide-, and lincosamide-classes was mainly associated with possession of tet(O), tet(S), erm(B), linB, and lnuD genes. CC996 was significantly associated with multidrug resistance (P<0.0001). These findings will aid Chiba farm animal clinics in treating bovine mastitis.</p>

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