Availability of Serum Levels of Carbohydrate Antigen 19-9 (CA19-9) as a Surrogate Tumor Marker for Papillary Thyroid Carcinoma
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- Kihara Minoru
- Departments of Surgery, Kuma Hospital, Kobe, Japan
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- Miyauchi Akira
- Departments of Surgery, Kuma Hospital, Kobe, Japan
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- Hirokawa Mitsuyoshi
- Diagnostic Pathology, Kuma Hospital, Kobe, Japan
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- Suzuki Ayana
- Diagnostic Pathology, Kuma Hospital, Kobe, Japan
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- Akamizu Takashi
- Internal Medicine, Kuma Hospital, Kobe, Japan
抄録
<p>Introduction: Thyroglobulin (Tg) is a very sensitive and specific marker in patients who have undergone total thyroidectomy for papillary thyroid carcinoma (PTC). However, the presence of a Tg antibody (TgAb) interferes with Tg immunometric assays, making Tg levels unreliable indicators. There are currently no other tumor markers to monitor in patients with PTC whose serum is TgAb-positive. Thus, we investigated whether carbohydrate antigen 19-9 (CA19-9) can be used as a tumor marker for PTC.</p><p>Methods: We retrospectively analyzed 196 consecutive patients with PTC (maximum diameter ≥ 2 cm). The serum CA19-9 and Tg values of each patient were obtained before and 0.5-1 month postsurgery. Immunohistochemical staining for PTC was performed using an antibody against CA19-9.</p><p>Results: High pre-surgery serum levels of CA19-9 were observed in 6.1% of the patients. Postsurgery, serum CA19-9 levels in all 196 patients decreased considerably and were within the normal range. CA19-9 expression was detected in 28 of 62 PTCs (45.2%) and was detected at various degrees and ranges in conventional PTC histology.</p><p>Conclusions: Although further studies with longer follow-ups are necessary, serum CA19-9 levels may serve as a surrogate tumor marker for PTC in place of serum Tg levels sin some patients.</p>
収録刊行物
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- JMA Journal
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JMA Journal 7 (2), 250-257, 2024-04-15
公益社団法人 日本医師会 / 日本医学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390863030854716288
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- ISSN
- 24333298
- 2433328X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可