Congenital Langerhans cell histiocytosis diagnosed early due to blistering: A case report

DOI

Bibliographic Information

Other Title
  • 水疱形成を契機に早期診断に至った先天性ランゲルハンス細胞組織球症の1例

Abstract

<p> Congenital Langerhans cell histiocytosis（LCH）is a rare inflammatory myeloid tumor. Skin lesions are common but not specific and it is difficult to make a diagnosis based on rash findings. Because of the poor prognosis of multisystem LCH, early pathological diagnosis by skin biopsy and therapeutic intervention are recommended. The patient was a male infant with a gestational age of 38 weeks and 0 days, weighing 2,356 g（‒1.67 standard deviation）. There were no abnormalities during pregnancy, and the baby was delivered vaginally without neonatal asphyxia. Since birth, reddish-brown scabs had spread all over the body and blisters were observed, and the newborn was transferred to our hospital for evaluation and treatment. After various tests failed to provide a definitive diagnosis, skin biopsies were performed and LCH was diagnosed at 23 days of age. Systemic examination revealed lesions in the lungs, liver, and bones, and the patient was treated with multidrug chemotherapy for multisystem LCH. We believe that it is necessary to consider LCH as congenital skin lesions with crusts and blisters, to perform skin biopsies proactively, and to collaborate with hematology/oncology specialists.</p>

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Keywords

Details 詳細情報について

  • CRID
    1390863041926433792
  • DOI
    10.34456/jjspnm.60.1_176
  • ISSN
    24354996
    1348964X
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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