A case of malignant transformation to angiosarcoma during long-term follow-up of a cervical schwannoma

DOI Web Site 12 References
  • Takeuchi Takuma
    Department of Otolaryngology and Head and Neck Surgery, Aichi Medical University Hospital
  • Nakamura Hiromu
    Department of Otolaryngology and Head and Neck Surgery, Aichi Medical University Hospital
  • Yamanaka Shunpei
    Department of Otolaryngology and Head and Neck Surgery, Aichi Medical University Hospital
  • Inukai Daisuke
    Department of Otolaryngology and Head and Neck Surgery, Aichi Medical University Hospital
  • Maruo Takashi
    Department of Otolaryngology and Head and Neck Surgery, Aichi Medical University Hospital
  • Ogawa Tetsuya
    Department of Otolaryngology and Head and Neck Surgery, Aichi Medical University Hospital
  • Fujimoto Yasushi
    Department of Otolaryngology and Head and Neck Surgery, Aichi Medical University Hospital

Bibliographic Information

Other Title
  • 頸部神経鞘腫の長期経過観察中に血管肉腫に悪性転化した一例

Abstract

We report a case of a schwannoma that underwent malignant transformation into an angiosarcoma. The patient was a 46-year-old male who visited our hospital for enlargement of a left cervical tumor and headache. CT imaging revealed a lesion, approximately 80mm in size, with well-defined margins, pronounced peripheral contrast enhancement, and suspected extensive hypovascular areas indicating potential bleeding or necrosis. While fine needle aspiration （FNA） detected malignancy, a detailed histological diagnosis was not reached. Tumor resection was performed for both diagnostic and therapeutic purposes, and because of the coexistence of schwannoma and angiosarcoma, the diagnosis of malignant transformation from schwannoma to angiosarcoma was confirmed. After surgery, bleeding from the early recurrent tumor persisted, making hemostasis challenging, but hemostasis was achieved through radiotherapy combined with paclitaxel. Subsequent administration of pazopanib resulted in a partial response （PR）, and the patient has been progression-free for 13 months. For schwannomas, when symptoms such as growth trends or pain are observed, resection is more strongly recommended, bearing in mind the possibility of malignant transformation.

Journal

  • Toukeibu Gan

    Toukeibu Gan 50 (1), 27-32, 2024

    Japan Society for Head and Neck Cancer

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