Genome 3D Structure Generated through Chromatin Movement

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  • FUJISHIRO Shin
    Fukui Institute for Fundamental Chemistry, Kyoto University
  • SASAI Masaki
    Fukui Institute for Fundamental Chemistry, Kyoto University Department of Complex Systems Science, Graduate School of Informatics, Nagoya University

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Other Title
  • クロマチン運動がつくるゲノム立体構造
  • クロマチン ウンドウ ガ ツクル ゲノム リッタイ コウゾウ

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Description

<p>Recent biochemical and microscopic measurements have revealed fluctuating chromatin structures of 10–7 to 10–5 m. These structures are intrinsically related to DNA transcription and replication; therefore, elucidating the physical principles of chromatin structural dynamics is essential for understanding cell functions. A three-dimensional computational model of the whole human genome was developed through the physics-based bottom-up approach, which quantitatively explained various genomic and microscopic data on chromatin. The model suggests that the difference in the functional activity among chromatin domains leads to the heterogeneous domain movement in the genome, which entropically drives chromatin phase separation to form A and B compartments.</p>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 64 (2), 78-84, 2024

    The Biophysical Society of Japan General Incorporated Association

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