TDM for sodium valproate, levetiracetam, and digoxin in home medical care using methods other than trough blood sampling

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  • 在宅医療におけるバルプロ酸ナトリウム，レベチラセタム，ジゴキシンのトラフ採血以外を用いたTDMの検討

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<p>Therapeutic drug monitoring (TDM) is used to evaluate blood concentrations of drugs whose therapeutic and side effect ranges are close to each other, and it is common to use blood concentrations immediately before administration (trough).</p><p>However, trough blood sampling is difficult in home medical care, and blood may be sampled after taking the drug. Therefore, this time, we used non-trough blood samples from patients taking sodium valproate levetiracetam, and digoxin to examine whether blood concentrations could be evaluated using predicted trough values calculated using analysis software.</p><p>As a result, it was considered useful to use the predicted trough value to evaluate side effects and compliance if blood was collected during the elimination phase, which was determined from drug characteristics, time elapsed after administration, and blood collection time.</p>

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