Risks of Dementia in a General Japanese Older Population With Preserved Ratio Impaired Spirometry: The Hisayama Study
-
- Kawatoko Kenji
- Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University
-
- Washio Yasuyoshi
- Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University
-
- Ohara Tomoyuki
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
-
- Fukuyama Satoru
- Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University Department of Respiratory Medicine, National Hospital Organization Omuta National Hospital
-
- Honda Takanori
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
-
- Hata Jun
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
-
- Nakazawa Taro
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
-
- Kan-o Keiko
- Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University
-
- Inoue Hiromasa
- Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University
-
- Matsumoto Koichiro
- Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University Division of Respiratory Medicine, Fukuoka Dental College Medical and Dental Hospital
-
- Nakao Tomohiro
- Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
-
- Kitazono Takanari
- Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
-
- Okamoto Isamu
- Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University
-
- Ninomiya Toshiharu
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
説明
<p>Background: Studies on the association between preserved ratio impaired spirometry (PRISm) and dementia are limited. Indeed, PRISm has often been overlooked or ignored as an index of lung function impairment. Therefore, we investigated the association of PRISm with the risk for the development of dementia in an older Japanese population.</p><p>Methods: A total of 1,202 community-dwelling, older Japanese participants aged ≥65 years without dementia were followed up for a median of 5.0 years. Participants were categorized by spirometry as follows: normal spirometry (FEV1/FVC ≥0.70 and FEV1 ≥80% predicted), PRISm (≥0.70 and <80%), airflow limitation (AFL) Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 (<0.70 and ≥80%), and AFL GOLD 2 to 4 (<0.70 and <80%). Hazard ratios (HRs) and their 95% confidence intervals (CIs) were computed using a Cox proportional hazards model.</p><p>Results: During the follow-up period, 122 participants developed dementia. The age- and sex-adjusted incidences of dementia in the participants with normal spirometry, PRISm, AFL GOLD 1, and AFL GOLD 2 to 4 were 20.5, 37.0, 18.4, and 28.6 per 1,000 person-years, respectively. Participants with PRISm had a higher risk of dementia (HR 2.04; 95% CI, 1.19–3.49) than those with normal spirometry after adjusting for confounders. Moreover, both reduced FEV1% predicted values and FVC% predicted values were associated with the risk of dementia.</p><p>Conclusion: PRISm was associated with an increased risk of dementia in a general older Japanese population.</p>
収録刊行物
-
- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
-
Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ 34 (7), 331-339, 2024-07-05
日本疫学会