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Effective Screening of Advanced Fibrosis in Patients with MASLD using the FIB-4 Index Combined with Metabolic Syndrome-Related Factors
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- Hosota Kanako
- Department of Gastroenterology, Bell Land General Hospital
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- Aihara Yosuke
- Department of Gastroenterology, Bell Land General Hospital
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- Kachi Hiroki
- Department of Gastroenterology, Bell Land General Hospital
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- Yokomura Akitaka
- Department of Gastroenterology, Bell Land General Hospital
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- Nakanishi Keisuke
- Department of Gastroenterology, Bell Land General Hospital
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- Hirose Satoru
- Department of Gastroenterology, Bell Land General Hospital
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- Ito Satoko
- Department of Gastroenterology, Bell Land General Hospital
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- Hoki Noriyuki
- Department of Gastroenterology, Bell Land General Hospital
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- An Tatsuichi
- Department of Gastroenterology, Bell Land General Hospital
Bibliographic Information
- Other Title
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- FIB-4 indexとメタボリックシンドローム関連因子を用いたMASLD線維化進展例の絞り込みの検討
- FIB-4 index ト メタボリックシンドローム カンレン インシ オ モチイタ MASLD センイカ シンテンレイ ノ シボリコミ ノ ケントウ
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Description
<p>A simple noninvasive index is desirable for patients with metabolic dysfunction-associated steatotic liver disease (MASLD). We investigated whether the FIB-4 index combined with metabolic syndrome-related factors (MSFs) including obesity, hypertension, diabetes mellitus, and dyslipidemia would be an effective primary screening tool for advanced fibrosis. Overall, this study included 223 patients with MASLD who underwent magnetic resonance elastography. They were divided into three risk groups using the FIB-4 index. In the intermediate-risk group, the FIB-4 index alone was insufficient for diagnosing advanced fibrosis; however, the proportion of cases with advanced fibrosis increased as the number of MSFs increased. The sensitivity, specificity, positive predictive value, and negative predictive value of F3- 4 cases were 0.792, 0.557, 0.306, and 0.915, respectively, when the cutoff of MSFs was defined by three factors. The combination of the FIB-4 index and the number of MSFs may be effective for identifying advanced fibrosis in patients with MASLD.</p>
Journal
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- Kanzo
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Kanzo 65 (10), 491-501, 2024-10-01
The Japan Society of Hepatology