Successful Treatment of Anaplastic Lymphoma Kinase (<i>ALK</i>) Fusion Gene-positive Small-cell Lung Cancer: a Case Report

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  • Yoshikawa Shuhei
    Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
  • Kikuchi Hajime
    Department of Respiratory Medicine, Obihiro-Kosei General Hospital
  • Kamada Ryohei
    Department of Respiratory Medicine, Obihiro-Kosei General Hospital
  • Okuda Takahisa
    Department of Respiratory Medicine, Obihiro-Kosei General Hospital
  • Mizobuchi Syohei
    Department of Respiratory Medicine, Obihiro-Kosei General Hospital
  • Yoshida Yukiko
    Department of Respiratory Medicine, Obihiro-Kosei General Hospital
  • Yamashita Yu
    Department of Respiratory Medicine, Obihiro-Kosei General Hospital
  • Takamura Kei
    Department of Respiratory Medicine, Obihiro-Kosei General Hospital
  • Kikuchi Keisuke
    Department of Pathology, Obihiro-Kosei General Hospital
  • Miura Ichiro
    Department of Clinical Laboratory, Obihiro Kyokai Hospital

Bibliographic Information

Other Title
  • アレクチニブが奏効した<i>ALK</i>融合遺伝子陽性小細胞肺癌の1例

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Description

<p>Background. Anaplastic lymphoma kinase (ALK) fusion gene-positive lung cancer is found in approximately 5% of cases of non-small-cell lung cancer, but there are few reports of small-cell lung cancer (SCLC) with ALK rearrangement. Case. A 47-year-old woman visited a nearby orthopedic hospital after noticing subcutaneous nodules. A subcutaneous nodule biopsy confirmed the diagnosis of small cell cancer, and she was admitted to our hospital. The diagnosis, based on a whole-body examination, was ALK fusion gene-positive SCLC cT4N3M1c stage IVB. As a first line therapy, she received chemotherapy of cisplatin and etoposide. However, after 1 cycle, her tumor marker levels remained slightly elevated and the tumor did not shrink. After initiating alectinib as a second-line therapy, the patient achieved a significant clinical response. Conclusion. We experienced a case in which ALK fusion gene-positive SCLC was successfully treated with alectinib.</p>

Journal

  • Haigan

    Haigan 64 (6), 854-859, 2024-10-20

    The Japan Lung Cancer Society

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