Microscale unorganized wrinkle topographies on biomaterial surfaces modulate cell migration

DOI Web Site 参考文献16件
  • Sasaki Saori
    Department of Mechanical Engineering, Faculty of Engineering, Kyushu University
  • Eguchi Keita
    Department of Mechanical Engineering, Graduate School of Engineering, Kyushu University
  • Wei Ming
    Department of Mechanical Engineering, Graduate School of Engineering, Kyushu University
  • Takahashi Ryu
    Department of Mechanical Engineering, Graduate School of Engineering, Kyushu University
  • Sera Toshihiro
    Department of Mechanical Engineering, Faculty of Engineering, Kyushu University Department of Medical and Robotic Engineering Design, Faculty of Advanced Engineering, Tokyo University of Science
  • Takeishi Naoki
    Department of Mechanical Engineering, Faculty of Engineering, Kyushu University
  • Kudo Susumu
    Department of Mechanical Engineering, Faculty of Engineering, Kyushu University

説明

<p>Directional migration of eukaryotic cells results from an interplay between cell motility and environmental cues such as stiffness, roughness, and microtopological features of substrates. While the effects of aligned grooves on the substrate lithographically designed on active cell migration are well documented, the impact of unorganized and wrinkled substrates remains poorly understood. We investigated how microscale wrinkles on gelatin substrates regulate two-dimensional (2D) migration of immortalized human mesenchymal stem cells (iMSCs). We showed that there exists an optimal wrinkle size to enhance iMSC migration, where the iMSCs exhibited larger travel distance with moderate wrinkle size (30 μm) than shorter or larger wrinkle sizes (10 μm and 50 μm). These findings reveal a size-dependent effect of wrinkles on iMSC migration and provide insights into designing biomaterials to control stem cell behavior in regenerative medicine applications.</p>

収録刊行物

  • Journal of Biorheology

    Journal of Biorheology 38 (2), 120-125, 2024

    特定非営利活動法人 日本バイオレオロジー学会

参考文献 (16)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ