Optimization of the structure of three-dimensional interconnected porous carbonate apatite bone grafts with spherical granules
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- TAKEDA Saki
- Department of Biomaterials, Faculty of Dental Science, Kyushu University Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
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- TSUCHIYA Akira
- Department of Biomaterials, Faculty of Dental Science, Kyushu University Institute of Environmental Science and Technology, The University of Kitakyushu
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- MORIYAMA Masafumi
- Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
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- ISHIKAWA Kunio
- Department of Biomaterials, Faculty of Dental Science, Kyushu University
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説明
<p>A block-type of three-dimensional carbonate apatite bone graft (3D-CO3Ap) is demanded for applying large bone defects. Although we fabricated the 3D-CO3Ap with high mechanical strength by fusing polymer-bound spherical precursor, the optimized condition has not yet been found. In this study, we indicated the optimized condition for 3D-CO3Ap by controlling granular packing ratio (i.e., different compression ratios of the mold volume from 100% to 140%). 3D-CO3Ap was obtained in the condition from 110% to 130%, even though the block was collapsed in 100% and complete conversion to CO3Ap was not achieved in 140%. The highest compressive strength was achieved with 130% 3D-CO3Ap because the intergranular connection area was the most enhanced. Furthermore, when reconstructing bone defects, 130% 3D-CO3Ap prevented soft tissue penetration and showed good osteoconductivity because of their controlled intergranular pore size. The 130% compression was optimal for achieving both high mechanical strength and osteoconductivity.</p>
収録刊行物
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- Dental Materials Journal
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Dental Materials Journal 44 (2), 233-240, 2025-03-25
一般社団法人 日本歯科理工学会
