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Effect of Using Spacers for Pressure Metered-Dose Inhalers (pMDI) on Aerosol Particle Distribution
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- NAKAGAWA Kazuto
- 日本大学生産工学部創生デザイン学科
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- KOEDA Fujio
- 日本大学芸術学部デザイン学科
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- ITO Reiko
- 日本大学医学部呼吸器内科
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- GON Yasuhiro
- 日本大学医学部呼吸器内科
Bibliographic Information
- Other Title
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- 加圧式定量噴霧式吸入器(pMDI)用スペーサーの利用によるエアロゾル粒子径分布への影響
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Description
<p>The issues with pressurized metered-dose inhaler (pMDI) used for inhalation therapy in respiratory diseases include the misalignment of spray timing and inhalation, which can lead to medication adhering in the oral cavity and potential side effects. Spacers allow the aerosolized medication to linger in the chamber, enabling the patient to inhale at their own timing, thus eliminating the need for synchronization of spraying and inhalation. However, the adherence of medication to the spacer’s interior can reduce the amount of medication that can be inhaled. In this study, we used a system combining an inhalation simulator and an aerodynamic particle sizer (APS) to replicate patients inhalation patterns and measure the amount of aerosolized medication and particle size distribution, investigating the impact of spacers on aerosolized particles. By using a spacer, the inhalation speed and volume do not affect the process, allowing approximately 80% of the aerosolized medication to be inhaled under appropriate conditions. However, at slower inhalation speeds, the influence of the one-way valve was observed, indicating that it is necessary to select a spacer that matches the inhalation speed. Additionally, the amount of medication available for inhalation decreased with prolonged retention time after spraying, suggesting that patients should be instructed to begin inhalation promptly after spraying.</p>
Journal
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- JOURNAL OF JAPAN SOCIETY FOR DESIGN ENGINEERING
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JOURNAL OF JAPAN SOCIETY FOR DESIGN ENGINEERING advpub (0), 2025
Japan Society for Design Engineering
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Keywords
Details 詳細情報について
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- CRID
- 1390866990078007552
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- ISSN
- 21889023
- 09192948
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed