Maternal Level of 25-Hydroxyvitamin D during Pregnancy Associated with Risk of Type 1 Diabetes in the Offspring, a Meta-Analysis
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- KANG Xinyi
- Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Nantong University (The First People’s Hospital of Nantong)
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- CUI Jiawen
- Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Nantong University (The First People’s Hospital of Nantong)
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- ZHANG Mingjin
- Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Nantong University (The First People’s Hospital of Nantong)
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- WANG Ying
- Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Nantong University (The First People’s Hospital of Nantong)
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- TANG Weichun
- Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Nantong University (The First People’s Hospital of Nantong)
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- CHEN Liping
- Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Nantong University (The First People’s Hospital of Nantong)
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Description
<p>This aim of this meta-analysis was to evaluate the association between risk of childhood type 1 diabetes and maternal 25-hydroxyvitamin D [25(OH)D] levels during pregnancy. A literature search on databases including PubMed and Embase was conducted up to December 2018. The pooled odds radio weighted mean difference (WMD) and the corresponding 95% confidence intervals (CIs) were calculated using the RevMan 5.3 software. A total of 4 studies were included in this meta-analysis. The overall analysis indicated that the maternal 25(OH)D levels during pregnancy was significantly associated with the risk of type 1 diabetes in offspring (WMD=−2.54, 95% CI=−4.65 to −0.44, p=0.02). The subgroup analyses showed that sample for detection vitamin D (serum/plasma) may not a factor influencing the results of this meta-analysis. However, gestational trimester may be a factor affecting the results. The results showed that no significant association was observed between risk of type 1 diabetes in offspring and 25(OH)D level during first or second gestational trimester (p>0.05). Lower maternal 25(OH)D levels during pregnancy is associated with higher risk of type 1 diabetes in offspring. Gestational trimester may be a factor influencing the results of this meta-analysis.</p>
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 66 (5), 402-408, 2020-10-31
Center for Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1391130851442601472
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- NII Article ID
- 130007932353
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- NII Book ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL BIB ID
- 030699239
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- PubMed
- 33132342
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed