Plasma exchange therapy inhibited the progression of anti-MAG antibody-associated polyneuropathy

Nakajima Eriko, Karube Miho, Nakajima Masanori, Shimoda Sachiko, Kunitomo Rie, Heryong Lee, Miyamoto Ayako, Takemori Ai, Kobayashi Satoshi, Kukimoto Hikaru, Uchibori Ayumi, Ichikawa Yaeko, Chiba Atsuro, Komagata Yoshinori, Kaname Shinya

doi:10.4009/jsdt.53.553

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血漿交換療法にて抗MAG抗体関連ニューロパチーの進行が抑制された1例
症例報告血漿交換療法にて抗MAG抗体関連ニューロパチーの進行が抑制された1例
ショウレイホウコクケッショウコウカンリョウホウニテコウMAG コウタイカンレンニューロパチーノシンコウガヨクセイサレタ 1レイ

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<p>The patient was a 75-year-old male with slowly progressive numbness and weakness in his distal limbs, who had been diagnosed with anti-MAG antibody-associated polyneuropathy (MAGN) at another hospital. Although rituximab, intravenous high-dose immunoglobulins, and methyl prednisolone were administered, the neuropathy progressed. Only plasma exchange alleviated the patient’s symptoms. His state was maintained by performing plasma exchange every 2 months for 4 years (total: 26 courses). Based on RCT results, rituximab is becoming the main treatment for MAGN, but in one-third of cases it is ineffective or worse; therefore, alternative treatments are needed. While some studies have found that plasma exchange has short-term effects against MAGN, no previous studies have shown that it has long-term effects against the condition. In our patient, long-term plasma exchange was effective against MAGN, suggesting that plasma exchange suppresses the progression of MAGN and is a useful maintenance therapy for the condition.</p>

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Nihon Toseki Igakkai Zasshi

Nihon Toseki Igakkai Zasshi 53 (11), 553-558, 2020

The Japanese Society for Dialysis Therapy

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