Mantle cell lymphoma with central nervous system relapse successfully treated with nasogastric-tube administration of ibrutinib

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  • 経鼻胃管からのイブルチニブ投与が有効であった中枢神経再発マントル細胞リンパ腫
  • ケイ ビ イカン カラ ノ イブルチニブ トウヨ ガ ユウコウ デ アッタ チュウスウ シンケイ サイハツ マントル サイボウ リンパシュ

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Abstract

<p>Central nervous system (CNS) involvement in mantle cell lymphoma (MCL) is uncommon. Here we present the case of a 70-year-old male patient who was diagnosed with classic MCL in 2015. The patient achieved complete remission (CR) in 2017 but relapsed with CNS involvement in 2019. He entered a deep coma and was treated with ibrutinib (560 mg daily) via nasogastric tube. He regained full consciousness after 15 days, and the presence of lymphoma cells in his cerebrospinal fluid disappeared 3 months later. We believe that ibrutinib administration via nasogastric tube is effective for MCL patients with CNS relapse.</p>

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  • Rinsho Ketsueki

    Rinsho Ketsueki 61 (10), 1508-1510, 2020

    The Japanese Society of Hematology

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