Antibacterial Effect of Burow’s Solution on Clinical Bacterial Isolates

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  • Hyo Yukiyoshi
    Departoment of Otolaryngology, Kawasaki Medical School
  • Ishimatsu Masaki
    Department of Clinical Laboratory, Kawasaki Medical School Hospital
  • Kouguchi Yutaka
    Department of Clinical Laboratory, Kawasaki Medical School Hospital
  • Yamada Sakuo
    Departoment of Microbiology, Kawasaki Medical School Department of Clinical Nutrition, Kawasaki Medical Welfare University
  • Saito Mineki
    Departoment of Microbiology, Kawasaki Medical School
  • Harada Tamotsu
    Departoment of Otolaryngology, Kawasaki Medical School

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Other Title
  • ブロー液における抗菌効果の細菌学的および超微形態学的検討
  • ブローエキ ニ オケル コウキン コウカ ノ サイキンガクテキ オヨビ チョウビケイタイガクテキ ケントウ

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Abstract

<p>Burow’s solution has long been used as a local otological preparation in the treatment of otitis externa and otitis media. To ascertain the antibacterial effect of Burow’s solution on the antibiotic resistant bacteria, it was examined using by the disk method to determine whether the solution has a bactericidal effect on Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae isolated from the patients. They were treated with 13% Burow’s solution. Ultrastructural changes in cells of the strains were examined by scanning electron microscopy (SEM) and transmission electron microscopy (TEM).</p><p>The results showed that Burow’s solution had larger average zones of inhibition than the other antibacterial agents (gentian violet). No difference was found in the susceptibilities of the antibiotic sensitive bacteria and resistant bacteria to Burow’s solution. This study suggests that Burow’s solution is an effective antibacterial agent, not only for antibiotic resistant bacteria but also for antibiotics-sensitive bacteria. Therefore, Burow’s solution is considered to be useful for the treatment of otitis. A further study is required to demonstrate whether diluted Burow’s solution is effective in the clinical setting. The microscopic findings show that Burow’s solution is active against this strains, resulting in damage to cell wall.</p>

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