Potential of human iPS cell-derived intestinal epithelial cells as a tool for pharmacokinetic assessment

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  • Yamashita Tomoki
    Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Yokota Jumpei
    Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Inui Tatsuya
    Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Mizuguchi Hiroyuki
    Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University Global Center for Medical Engineering and Informatics, Osaka University Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition

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Other Title
  • 薬物動態評価系としてのヒトiPS細胞由来腸管上皮細胞の可能性
  • ヤクブツ ドウタイ ヒョウカケイ ト シテ ノ ヒト iPS サイボウ ユライ チョウカン ジョウヒ サイボウ ノ カノウセイ

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Abstract

The efficient development of safe, orally administered drugs requires accurate prediction of pharmacokinetics in the patient’s intestine at the preclinical stage. However, the current in vitro intestinal pharmacokinetic assay systems have several drawbacks, including species differences and low（or no） expression of drug-metabolizing enzymes and transporters. Therefore, it is expected that intestinal epithelial cells generated from human iPS cells（human iPS cell-derived intestinal epithelial cells） will be used to evaluate the pharmacokinetics of drugs in the human intestinal tract. There are two main methods for generating human iPS cell-derived intestinal epithelial cells: those involving three-dimensional culture（intestinal organoids） and those involving consistent two-dimensional culture. In this review, we discuss the pharmacokinetic applications of human iPS cell-derived intestinal epithelial cells generated by each method.

Journal

  • Drug Delivery System

    Drug Delivery System 35 (4), 309-318, 2020-09-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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