Structure Activity Relationship Study of Polymethoxylated Flavones Targeted Retinal Müller Cells for Prevention of Retinal Diseases

Miyata Yoshiki

doi:10.1248/yakushi.20-00177-2

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網膜ミュラー細胞を標的とする網膜疾患予防へ向けた新規ポリメトキシフラボン類の構造活性相関研究
モウマクミュラーサイボウオヒョウテキトスルモウマクシッカンヨボウエムケタシンキポリメトキシフラボンルイノコウゾウカッセイソウカンケンキュウ

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<p>Diabetic retinopathy (DR) is a retinal disease representing one of the main causes of vision loss in developed countries. In the early stage of DR, disruption of blood retinal barrier (BRB) is observed, and it will lead to vascular permeability and visual impairment. Therefore, protection against the breakdown of BRB may be useful strategy for prevention of DR. Matrix metalloproteinases (MMPs) plays an important role in the degradation of extracellular matrix proteins. In DR, they attribute to increased vascular permeability by degrading the junction proteins, such as occuldin and cadherin that are important to maintain the BRB junction complex. Müller cells constitute the main glial cells of the retina and are involved in many retinal functions. They are reported to be one of the MMP-producing cells in the retina. In this symposium review, I present the molecular mechanism of MMP expression in retinal Müller cells. In addition, I would like to introduce polymethoxylated flavones, nobiletin and the derivatives isolated from natural resource as novel MMP inhibitors, which may be applicable to prevention of DR.</p>

Journal

YAKUGAKU ZASSHI

YAKUGAKU ZASSHI 141 (1), 41-45, 2021-01-01

The Pharmaceutical Society of Japan

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