Synthesis and Properties of Cleavable Quaternary Ammonium Compounds

Gilbert Elangeni A., Guastavino Javier F., Nicollier Rocío A., Lancelle María Verónica, Russell-White Karen, Murguía Marcelo C.

doi:10.5650/jos.ess20216

<p>Quaternary ammonium compounds are widely used as antiseptic and disinfectant. It is been a concern that their widespread use will lead to an increase of environmental problems, therefore the development of biodegradable surfactants is necessary. The present research is aimed at the design of novel amphiphilic molecules with similar properties to those already known but more biodegradable. Based on benzalkonium chloride (BAC), novel carbonate cleavable surfactants (CBAC) were synthesized. The breakable carbonate sites make CBAC compounds more degradable and potentially more biodegradable than their non-cleavable BAC analogues. Natural products such as fatty alcohols (C₈-C₁₆) and N,N-dimethyl-2-aminoethanol were used as reagents for the synthesis of CBAC8-16. These amphiphilic compounds were characterized in terms of surface properties and antimicrobial activity against Gram-positive and Gram-negative bacteria, yeasts and moulds. The novel surfactants showed similar surface activities in aqueous solutions when compared to BAC. Also, the surface activity/structure relationship revealed that carbonate cleavable surfactants with n-decyl group (CBAC10) showed the same behaviour as non-cleavable BAC. Furthermore, compounds containing n-octyl (CBAC8), n-decyl (CBAC10) and n-dodecyl (CBAC12) group showed strong antimicrobial activities.</p>

Synthesis and Properties of Cleavable Quaternary Ammonium Compounds

書誌事項

この論文をさがす

説明

収録刊行物

参考文献 (18)*注記

キーワード

詳細情報詳細情報について

書き出し

問題の指摘

Synthesis and Properties of Cleavable Quaternary Ammonium Compounds

書誌事項

この論文をさがす

説明

収録刊行物

参考文献 (18)*注記

キーワード

詳細情報 詳細情報について

書き出し

問題の指摘

詳細情報詳細情報について