Evolutionary origin of the eukaryotic cellular membrane and its geobiological implications

DOI

Bibliographic Information

Other Title
  • 真核生物の細胞膜進化とステロイド・バイオマーカーの起源

Description

<p>Steroids are indispensable components of the eukaryotic cellular membrane and have important roles in the process of endocytosis. Steroids are characteristic of eukaryotic organisms and hence have been utilized as biomarkers for eukaryotes in the Precambrian geological record. It is generally inferred that steroids biosynthesis evolved within eukaryotes, while the steroid biosynthesis in a small number of bacteria is a result of horizontal gene transfers from eukaryotes. However, more bacteria have been found to possess a steroid biosynthesis pathway and the traditional understanding of the steroid evolution is now called into question.Our current study suggests that the entire eukaryotic steroid biosynthesis pathway is derived from bacteria. Almost all genes that are involved in the steroid biosynthesis up to cholesterol are inferred to have evolved within the bacterial domain. However, the evolutionary trajectory for individual genes seems to be different from one another. Hence, the evolution of the eukaryotic isoprenoid biosynthesis pathway is inferred to have been a multi-step process that was triggered by the rise of molecular oxygen at Great Oxidation Event.</p>

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Details 詳細情報について

  • CRID
    1391131406309778176
  • NII Article ID
    130007977222
  • DOI
    10.14862/geochemproc.67.0_64
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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