Study of general local residents's relationship between oral environment and oral bacterial flora

Noguchi Takao, Ishizaki Hiroshi, Tamura Yoshihiro, Oyama Toshiaki, Osanai Toshiyuki, Satake Anna, Fukuta Haruka, Akiyama Natsumi, Sawada Kaori, Ihara Kazushige, Nakaji Shigeyuki, Kobayashi Wataru

doi:10.32216/hirosakiigaku.71.1_46

Among several oral bacteria, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola which are assumed to cause invasive periodontal disease are called Red complex. It is known that these bacteria influence oral health and enhance a risk of systemic diseases. A lot of attention has been paid to the influence of these bacteria on human health along with the intestinal microflora. In the present study, we focused on the periodontal disease-related pathogens especially the Red complex which were isolated from tongue coating, and their epidemiological relationship to the oral environment was investigated. By the next-generation sequencing analysis, 43 bacterial genera from 1,063 Hirosaki city’s residents were detected. Thirteen bacterial genera which are likely to affect the periodontal disease were selected and their relationship to the oral environment was examined. Moreover, the factors affecting to the Red complex was investigated by the multiple regression analysis. The factors which affect the Red complex are the presence of periodontal disease（ P=0.000002）, age（ P=0.00008）, numbers of caries tooth（ P=0.0002） and smoking （P=0.008）. These results demonstrated that the Red complex exists not only in periodontal pocket but also in tongue coating and it is related to the oral environment.

Study of general local residents's relationship between oral environment and oral bacterial flora

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