Changes in therapies for surgical infectious diseases due to AST activities

DOI
  • Yamada Koichi
    Department of Infection Control and Prevention, Osaka City University Hospital
  • Kuwabara Gaku
    Department of Infection Control and Prevention, Osaka City University Hospital
  • Kakeya Hiroshi
    Department of Infection Control and Prevention, Osaka City University Hospital

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  • AST活動による外科感染症診療の変化

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Abstract

<p>We implemented “Prospective audit and Feedback” as core strategy of ASP. We evaluated the effectiveness of surgical infection treatment for all bacteremia and Bacteroides, which are frequently the cause of surgical infections. As a result, the rate of two sets of blood culture increased and the in–hospital mortality rate of bacteremia was significantly improved (34.9％→23.1％: P＝0.04). In Bacteroides bacteremia, AST activity decreased the frequency of carbapenem agents used in empirical treatment and increased TAZ/PIPC. In addition, the de–escalation rate in definitive therapy increased (9.7％→34.8％: P=0.04). No obvious change in susceptibility to Bacteroides was observed. The prognosis of bacteremia tended to be improved. From the above, it was shown that the AST activities in our hospital is effective in the treatment of surgical infectious diseases.</p>

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