Performance evaluation of the serum-soluble interleukin 2 receptor (sIL-2R) measurement reagents “Lumipulse Presto IL-2R” and “Nanopia IL-2R”

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  • KUZUMI Hirotoshi
    Department of Clinical Laboratory Medicine, Shizuoka General Hospital, Shizuoka Prefectural Hospital Organization
  • OISHI Yuu
    Department of Clinical Laboratory Medicine, Shizuoka General Hospital, Shizuoka Prefectural Hospital Organization
  • MURAKOSHI Daiki
    Department of Clinical Laboratory Medicine, Shizuoka General Hospital, Shizuoka Prefectural Hospital Organization
  • SHIRAKAWA Rumi
    Department of Clinical Laboratory Medicine, Shizuoka General Hospital, Shizuoka Prefectural Hospital Organization
  • HIRAMATSU Naoki
    Department of Clinical Laboratory Medicine, Shizuoka General Hospital, Shizuoka Prefectural Hospital Organization
  • SONODA Akihiro
    Clinical Research Center, Shizuoka General Hospital, Shizuoka Prefectural Hospital Organization
  • SHIMADA Toshio
    Clinical Research Center, Shizuoka General Hospital, Shizuoka Prefectural Hospital Organization

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  • 可溶性インターロイキン2受容体（sIL-2R）測定試薬『ルミパルスプレストIL-2R』と『ナノピアIL-2R』の性能評価

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<p>The serum-soluble interleukin-2 receptor has been used as a diagnostic aid for malignant lymphoma and as an indicator of treatment follow-up. In this study, we compared the performance of reagents by chemiluminescent enzyme immunoassay (CLEIA; Lumipulse Presto IL-2R, manufactured by Fujirebio Co., Ltd.) and latex turbidimetric immunoassay (Nanopia IL-2R, manufactured by Sekisui Medical Co., Ltd.). Furthermore, we compared the correlation of CLEIA using these reagents with the outsourced assay (Determiner CL IL-2R, Hitachi Chemical Diagnostics Systems Co., Ltd.) and evaluated the suitability of these reagents in in-hospital measurement. The performance of both reagents was satisfactory and sufficient for daily measurements. However, since Nanopia IL-2R showed nonspecific reactions in some samples, it is desirable to use it considering the occurrence of nonspecific reactions. It is possible to immediately select the appropriate treatment method and expect a clinical diagnostic contribution by reporting the results on the same day.</p>

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