Metabolic Groups Related to Blood Vitamin Levels and Inflammatory Biomarkers in Brazilian Children and Adolescents
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- ALMADA Maria Olímpia Ribeiro do Vale
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo
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- ALMEIDA Ane Cristina Fayão
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo
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- UED Fábio da Veiga
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo
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- MATHIAS Mariana Giaretta
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo
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- COELHO-LANDELL Carolina de Almeida
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo
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- SALOMÃO Roberta Garcia
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo
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- TOFFANO Roseli Borges Donegá
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo
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- CAMARNEIRO Joyce Moraes
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo
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- HILLESHEIM Elaine
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo
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- BARROS Tamiris Trevisan de
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo
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- CAMELO-JUNIOR José Simon
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo
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- MOCO Sofia
- Nestlé Institute of Health Sciences, École Polytechnique Fédérale de Lausanne
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- KAPUT Jim
- Nestlé Institute of Health Sciences, École Polytechnique Fédérale de Lausanne
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- MONTEIRO Jacqueline Pontes
- Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo
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<p>Certain B-vitamins and vitamin A may be involved in inflammatory pathways associated with homocysteine and omega-3 fatty acids. The aims of this study were (i) to determine whether different metabolic profiles of B-vitamins and vitamin A in Brazilian children and adolescents were positively or negatively related to homocysteine and omega-3 fatty acids using k-means clustering analysis, (ii) compare nutrient intakes and metabolites between the different metabolic profiles, (iii) evaluate if the statistically significant metabolites found between the metabolic groups, can predict the variation of leukotriene A4 hydrolase (LTA4H) levels, a biomarker of low-grade inflammation, in the total studied population. This cross-sectional study included 124 children and adolescents, aged 9-13 y old. Dietary intake was assessed by the food frequency questionnaire and 24-hour recall. Biomarkers for vitamins B2, B6, B12, folate and vitamin A were measured in plasma. Omega-3 fatty acids and homocysteine were measured in red blood cells (RBC). Two different metabolic profiles were found. Thirty of these individuals had overall average higher riboflavin, pyridoxal, and vitamin B12 plasma levels (metabolic group 1) compared to 94 individuals (group 2). Group 2 had lower dietary intake of vitamin B2, vitamin A, and vitamin B12 and higher RBC levels of homocysteine. EPA and DHA erythrocyte levels were not different between metabolic groups. Multiple linear regression analyses showed that blood cobalamin, riboflavin, pyridoxal and homocysteine combined, explained 9.0% of LTA4H levels variation in the total studied population. The metabolic group that had low plasma levels of riboflavin, pyridoxal, and cobalamin also had a lower dietary intake of B-vitamin and higher RBC homocysteine. The combined levels of the riboflavin, pyridoxal, cobalamin and homocysteine biomarkers can predict the variation of LTA4H in the total population studied, but it is not clear how this regulation occurs.</p>
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- Ｊｏｕｒｎａｌ ｏｆ Ｎｕｔｒｉｔｉｏｎａｌ Ｓｃｉｅｎｃｅ ａｎｄ Ｖｉｔａｍｉｎｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｎｕｔｒｉｔｉｏｎａｌ Ｓｃｉｅｎｃｅ ａｎｄ Ｖｉｔａｍｉｎｏｌｏｇｙ 66 (6), 515-525, 2020-12-31
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詳細情報 詳細情報について
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- CRID
- 1391412881271556224
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- NII論文ID
- 130007964466
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 031199036
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- PubMed
- 33390393
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可