A Clinical and Bacteriological Study of Children Suffering from Haemolytic Uraemic Syndrome in Tucuman, Argentina

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  • Miceli Susana
    Servicio de Nefrología, Hospital del Niño Jesús (Nephrology Department, Children's Hospital), Argentina
  • Jure María Angela
    Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán (UNT), Argentina CERELA (Centro de Referencias para Lactobacilos) (Lactobacillus Reference Centre), Argentina
  • Saab Olga A de
    Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán (UNT), Argentina
  • Castillo Marta C de
    Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán (UNT), Argentina
  • Rojas Susana
    Servicio de Nefrología, Hospital del Niño Jesús (Nephrology Department, Children's Hospital), Argentina
  • Holgado Aída P de Ruiz
    Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán (UNT), Argentina CERELA (Centro de Referencias para Lactobacilos) (Lactobacillus Reference Centre), Argentina
  • Nader Olga M de
    Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán (UNT), Argentina

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  • A Clinical and Bacteriological Study of Children Suffering from Haemolytic Uraemic Syndrome in Tucmán, Argentina

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<p>Haemolytic uraemic syndrome (HUS) is a disease with serious consequences for children, such as terminal chronic renal failure. During the last few years there have been numerous studies undertaken to determine whether there is a relationship between this disease and the presence of Shiga toxin-producing bacteria. Escherichia coli (E. coli) O157:H7 is one of the most frequent etiologic agents of HUS. It acts through cytotoxins called Shiga toxin 1 (Stx1) and/or Shiga toxin 2 (Stx2) and carries a 90-Kb plasmid codified for an adhesion fimbria which is part of its pathogenicity. The objectives of this study were to: 1) confirm whether there exists a relationship between severity and clinical presentation of HUS; 2) prove the existence of Stx1 and/or Stx2 in the faeces of HUS patients; and 3) detect the presence of Stx1- and/or Stx2-producing E. coli. Our results did not show any difference in the average age, sex or clinical behavior between children with diarrhea positive (D+) HUS and diarrhea negative (D-) HUS. Male patients were predominant, as was incidence during summer, considering all cases. Nor could we find any relationship between severity and HUS type. E. coli O157:H7 was isolated in 40% of the patients with (D+) HUS and in 50% of patients with (D-) HUS. Another serotype, O55:K59, was also isolated (7%). Stx1 and/or Stx2 were found in all HUS cases. The following virulence factors of E. coli strains isolated from 12 patients were found: Adhesion fimbria (100%), Stx1 (16%), Stx2 (32%), and Stx1 + Stx2 (50%). None of these factors was found in control patients. Sixty-three percent of the HUS cases showed seroconversion for lipopolysaccharides of E. coli O157. We drew the following conclusions: 1) there is no significant relationship between seriousness of HUS and type of disease; 2)an association exists between HUS and the production of Stx1 and Stx2; 3) the incidence of E. coli O157:H7 was high in Tucuman, Argentina; and 4) Stx2 alone or in association with Stx1 was the predominant toxin.<tt> </tt></p>

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