CYCLIC ALTERATION OF ELECTROPHORETIC PROPERTY ASSOCIATED WITH GROWTH CIRCLE IN HELA S3 CELLS

DOI 機関リポジトリ PubMed オープンアクセス
  • TSUNOO Hajime
    Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University
  • YAMADA Takashi
    Department of Pathology, Dokkyo University, School of Medicine
  • ASO Kunio
    Department of Internal Medicine, Atsukeshi Hospital, Hokkaido

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説明

Changes of electrical cell-surface charge associated with cell cycle were examined electrophoretically in the synchronous culture of HeLa S3 cells. The electrophoretic mobility of the cells increased abruptly in the mitotic phase as high as 45% compared with that of cells in the S phase. This difference of mobility was obtained by comparing pure population of mitotic cells and S-phase cells. Mitotic cells were also found to be more susceptible to neuraminidase than S-phase cells in term of electrophoretic mobility, a greater amount of sialic acid being correspondingly released from the former. The mechanism of the electrokinetic change associated with the processes of cell cycle is discussed, with special reference to the distribution of electric charge in the cell surface membrane.

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詳細情報 詳細情報について

  • CRID
    1391693801395289472
  • NII論文ID
    130007942085
  • DOI
    10.11480/btmd.240202
  • ISSN
    24350761
    00408921
  • PubMed
    267515
  • Web Site
    http://id.nii.ac.jp/1569/00000803/
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • JaLC
    • IRDB
    • CiNii Articles
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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