Multimodal therapy of metachronous anaplastic pancreatic carcinomas including two pancreatic resections

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  • 2回の膵切除手術によって長期生存した退形成性膵管癌の異時性重複発生の1例

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Abstract

<p>A 70-year-old man was diagnosed with carcinoma of the pancreatic head because of worsening diabetes, and pancreatoduodenectomy was performed. The tumor was 9mm in diameter (TS1 in JPS classification), and histopathological examination revealed an osteoclast-like giant cell-type anaplastic pancreatic carcinoma. Twenty-nine months after surgery, abdominal CT scan revealed a 22-mm mass in the residual pancreatic body with a dilated pancreatic duct, indicating another tumor. Residual pancreatectomy (total pancreatectomy) was then performed. Histopathologically, a spindle cell-type anaplastic carcinoma was found that was different from the subtype of the initial anaplastic carcinoma. We regarded this as a new lesion, not a recurrence of the initial one. This is the first report in Japan of metachronous anaplastic pancreatic carcinomas with different subtypes. Anaplastic pancreatic carcinoma is very rare and is associated with a poor prognosis. The current patient achieved long-term survival with multimodal therapy including two pancreatic resections. Aggressive surgical treatment can contribute to the prognosis of patients with this disease.</p>

Journal

  • Suizo

    Suizo 35 (5), 439-446, 2020-10-30

    Japan Pancreas Society

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