Improved Risk Stratification of Patients With Brugada Syndrome by the New Japanese Circulation Society Guideline ― A Multicenter Validation Study ―
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- Wakamiya Akinori
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Department of Cardiology, Faculty of Medicine, University of Tsukuba
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- Kamakura Tsukasa
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Shinohara Tetsuji
- Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
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- Yodogawa Kenji
- Department of Cardiovascular Medicine, Nippon Medical School
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- Murakoshi Nobuyuki
- Department of Cardiology, Faculty of Medicine, University of Tsukuba
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- Morita Hiroshi
- Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
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- Takahashi Naohiko
- Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
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- Inden Yasuya
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Shimizu Wataru
- Department of Cardiovascular Medicine, Nippon Medical School
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- Nogami Akihiko
- Department of Cardiology, Faculty of Medicine, University of Tsukuba
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- Horie Minoru
- Center for Epidemiologic Research in Asia and Department of Cardiovascular Medicine, Shiga University of Medical Science
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- Nakajima Kenzaburo
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Kataoka Naoya
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Wada Mitsuru
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Yamagata Kenichiro
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Ishibashi Kohei
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Inoue Yuko
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Miyamoto Koji
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Nagase Satoshi
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Noda Takashi
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Aiba Takeshi
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Yasuda Satoshi
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Ieda Masaki
- Department of Cardiology, Faculty of Medicine, University of Tsukuba
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- Kusano Kengo
- Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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Description
<p>Background:The new guideline (NG) published by the Japanese Circulation Society (JCS) places emphasis on previous arrhythmic syncope and inducibility of ventricular fibrillation (VF) by ≤2 extrastimuli during programmed electrical stimulation (PES) for deciding the indication of an implantable cardioverter-defibrillator in patients with Brugada syndrome (BrS). This study evaluated the usefulness of the NG and compared it with the former guideline (FG) for risk stratification of patients with BrS.</p><p>Methods and Results:This was a multicenter (7 Japanese hospitals) retrospective study involving 234 patients with BrS who underwent PES at baseline (226 males; mean age at diagnosis: 44.9±13.4 years). At diagnosis, 46 patients (20%) had previous VF, 100 patients (43%) had previous syncope, and 88 patients (37%) were asymptomatic. We evaluated the difference in the incidence of VF in each indication according to the new and FGs. During the follow-up period (mean: 6.9±5.2 years), the incidence of VF was higher in patients with Class IIa indication according to the NG (NG: 16/45 patients [35.6%] vs. FG: 16/104 patients [15.4%]), while the incidence of VF in patients with other than class I or IIa indication was similarly low in both guidelines (NG: 2/143 patients [1.4%] vs. FG: 2/84 patients [2.4%]).</p><p>Conclusions:This study validated the usefulness of the NG for risk stratification of BrS patients.</p>
Journal
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- Circulation Journal
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Circulation Journal 84 (12), 2158-2165, 2020-11-25
The Japanese Circulation Society
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Keywords
Details 詳細情報について
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- CRID
- 1391693801399746048
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- NII Article ID
- 130007942469
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL BIB ID
- 031210982
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- PubMed
- 33071242
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed