メソポーラスシリカを用いた光応答性ドラッグデリバリー

DOI Web Site Web Site 参考文献18件
  • 藤原 正浩
    国立研究開発法人産業技術総合研究所 化学プロセス研究部門

書誌事項

タイトル別名
  • Photo Responsive Drug Delivery System (DDS) Using Mesoporous Silica
  • メソポーラスシリカ オ モチイタ ヒカリ オウトウセイ ドラッグデリバリー

この論文をさがす

抄録

Targeted drug delivery system (DDS) triggered by photo irradiation is described in this paper. A mesoporous silica with a coumarin substituent grafted to the outlet region can store a drug molecule in its mesopore, when the coumarin is dimerized by the irradiation of longer wavelength UV light to close the gate of the mesopore. The drug molecule carried to target part can be released from the mesopore by the cleavage of the coumarin dimer triggered by the irradiation of shorter wavelength UV light. The continuous photo isomerization of azobenzene induced by the simultaneous irradiation of UV and visible light promotes the release of a drug molecule from the mesopore. Double modified mesoporous silica with the coumarin and the azobenzene substituents realizes an advanced targeted drug delivery. Using this silica, both the release and the release rate of drug molecule in the mesopore can be controlled by photo irradiations.

収録刊行物

  • レーザー研究

    レーザー研究 45 (11), 691-, 2017

    一般社団法人 レーザー学会

参考文献 (18)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ