Serum level of MMP-9 Is Associated with the Risk of Intracranial Major Vessel Atherosclerosis in Patients with Carotid Atherosclerosis

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  • Soga Kaima
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Shimizu Takahiro
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Iijima Naoki
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Takao Naoki
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Tsuchihashi Yoko
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Shibata Soichiro
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Ogura Hana
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Hagiwara Yuta
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Kuwata Chihiro
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Sasaki Naoshi
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Akiyama Hisanao
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Hasegawa Yasuhiro
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine Division of Neurology, Department of Internal Medicine, Shin-Yurigaoka General Hospital
  • Yamano Yoshihisa
    Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine

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  • 頸動脈狭窄患者において血清MMP-9濃度は頭蓋内主幹動脈狭窄リスクと関連する

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<p>Background<br/>In patients with extracranial carotid atherosclerotic disease (ECAD), comorbid intracranial atherosclerotic disease (ICAD) causes high stroke recurrence and mortality rates. We hypothesized that the properties of carotid atherosclerosis are related to the risk of ICAD; however, this hypothesis has not been confirmed. Therefore, we aim to clarify the factors associated with the risk of ICAD in patients with carotid artery stenosis by measuring the properties of carotid atherosclerosis and arteriosclerosis-related biomarkers.<br/>Materials & Methods<br/>A total of 50 patients with atherosclerotic carotid artery stenosis were included in the study. ICAD was defined as stenosis of 50% or greater, affecting the large intracranial arteries on magnetic resonance angiography. The associations between carotid atherosclerosis properties measured via magnetic resonance imaging (MRI) black blood method, ultrasonography, and arteriosclerosis-related biomarkers (oxidized LDL, LOX-1, MPO, PTX3, MMP-9, hsCRP) were examined using univariate analysis between patients with and without ICAD.<br/>Results<br/>ICAD was detected in 15 of 50 patients (30%), all of whom had middle cerebral artery stenosis. Univariate analysis revealed associations between ICAD and the MMP9 value (p=0.03) and the high-sensitivity CRP value (p=0.02).<br/>Conclusion<br/>In patients with atherosclerotic carotid artery stenosis, the serum MMP-9 level was associated with the risk of ICAD while other markers of atheromatous plaques, detected by MRI and carotid ultrasonography, were not. These results may suggest a role for MMP-9 in the progression of ICAD.</p>

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