Structure of Lipophilic Vitamin Nanoemulsions and Membrane Permeability

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  • 脂溶性ビタミンナノエマルションの構造と膜透過
  • シヨウセイ ビタミンナノエマルション ノ コウゾウ ト マク トウカ

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Abstract

<p>Nanoemulsions of a lipophilic vitamin A (VA) have a therapeutic effect on corneal damage. The nanoemulsion with a triblock-type polymer surfactant F127 (EOPO) showed superior efficacy. To understand the mechanism of the efficacy of EOPO nanoemulsions, we studied their inner structure and their interaction to corneal epithelial cell. It was found that they had a partially exposed vitamin core interface and interacted with lipid bilayer by their hydrophobicity. Accordingly, EOPO nanoemulsions induced the endocytic morphological changes on giant unilamellar vesicles (GUVs) and the plasma membrane of corneal epithelial cell, and promoted the membrane permeability and the efficacy of VA.</p>

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