The Protective Effects of Protein-Enriched Fraction from Housefly (Musca domestica) against Aged-Related Brain Aging

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  • TANG Yanan
    School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University
  • FENG Panpan
    Guangdong Lingnan Institute of Technology
  • GUI Shuiqing
    Intensive Care Unit, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University
  • JIN Xiaobao
    School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University
  • ZHU Jiayong
    School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University
  • LU Xuemei
    School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University

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  • The Protective Effects of Protein-Enriched Fraction from Housefly (<i>Musca domestica</i>) against Aged-Related Brain Aging

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<p>The Musca domestica larvae are well known for its multifunctions and great nutritional value. The present study aimed at investigating the beneficial effect of Musca domestica larvae extract (Mde) against memory impairment, structural damage and oxidative stress in aged rats. Twenty-month-old rats were gavaged with Mde for 2 mo. Morris Water Maze test indicated Mde prevented aging-induced spatial learning and memory dysfunction in the aged rats. Mde supply was also found to attenuate age-associated changes of brain histology that observed by light microscopy and transmission electron microscopy. Moreover, the increase of antioxidant capacity, glutathione peroxidase (GPx) activity, superoxide dismutase (SOD) activity, as well as the decreased methane dicarboxylic aldehyde (MDA) levels, were consistent with these results. Hence, we propose that oral administration of Mde could improve memory impairment via antioxidant action, and Mde has the potential to act as an excellent food supplement or medicine for the attenuation of brain aging.</p>

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