Effective Intravenous Administration of Dexmedetomidine to Prevent Emergence Agitation after General Anesthesia in a Pediatric Patient with Osteogenesis Imperfecta

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  • MATSUI Sakiyo
    Department of Anesthesiology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama
  • HONDA Yasuko
    Department of Anesthesiology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama
  • SAKAMOTO Natsumi
    Department of Anesthesiology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama
  • YAMAZAKI Mitsuaki
    Department of Anesthesiology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama

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  • デクスメデトミジン持続投与が覚醒時興奮の抑制に有用であった，骨形成不全症患児に対する全身麻酔経験

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Abstract

<p>Osteogenesis imperfecta（OI）is a congenital disease characterized by bone fragility. Care must be taken to avoid additional bone fractures because of perioperative excitement in pediatric patients with OI undergoing surgery. We performed entropion surgery under general anesthesia in a 7-year-old girl with OI who had previously experienced multiple fractures. She received a bromazepam suppository（3 mg）before entering the operating room to prevent excitement during induction of anesthesia. Induction was successful with sevoflurane and oxygen. After tracheal intubation, we changed sevoflurane to continuous administration of propofol. Dexmedetomidine（0.4 µg/kg/h）was started to prevent emergence agitation（EA）. Propofol was stopped after surgery and dexmedetomidine was continued after extubation. The patient did not show EA on awakening and was extubated safely. Dexmedetomidine has recently been reported to be effective for preventing EA in pediatric patients, and was effective in our case with OI as well.</p>

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