書誌事項
- タイトル別名
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- Photoresponsive Gene Delivery System: Photoregulation of Intracellular Trafficking Using Photoresponsive Liposome
- ヒカリ ニ オウトウ スル イデンシ デリバリー システム : エンドソーム ダッシュツ オ チュウシン ト シタ サイボウ ナイ トラフィッキング ヒカリ セイギョ
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説明
Since light as a stimulus can be controlled both temporally and spatially, photo-irradiation improves both the endosomal escape of exogenous DNA and DNA release from the complexes with carriers. When a photo-responsive cationic lipid formed a cell-sized giant vesicle, we observed the photo-isomerization effect of azobenzene on its shape change. Photoswitching the membrane line tension induced reversible transitions between a closed sphere and an opened disk with a bilayer pore. In a transfection experiment using a photoresponsive cationic lipid, UV irradiation improved the transfection efficiency. After the lipoplexes passed through the plasma membrane by endocytosis, trans to cis isomerization of azobenzene moiety destabilized the vesicle membrane, thus accelerating not only the membrane fusion of the photoresponsive lipid vesicles but also the endosomal escape of the exogenous DNA.
収録刊行物
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- レーザー研究
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レーザー研究 45 (11), 696-, 2017
一般社団法人 レーザー学会
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詳細情報 詳細情報について
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- CRID
- 1391975831220761728
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- NII論文ID
- 130007957346
- 40021404838
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- NII書誌ID
- AN00255326
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- ISSN
- 13496603
- 03870200
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- NDL書誌ID
- 028706067
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
