Clinical Course and Prognosis of Acute Rheumatic Fever with Carditis in Six Patients

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  • Ishiodori Takumi
    Department of Pediatrics, University of Tsukuba Hospital
  • Horigome Hitoshi
    Department of Child Health, Faculty of Medicine, University of Tsukuba Department of Pediatric Cardiology, Ibaraki Children’s Hospital
  • Yano Yusuke
    Department of Pediatrics, University of Tsukuba Hospital
  • Shima Yuriko
    Department of Pediatrics, University of Tsukuba Hospital
  • Nozaki Yoshihiro
    Department of Child Health, Faculty of Medicine, University of Tsukuba
  • Ishikawa Nobuyuki
    Department of Pediatrics, University of Tsukuba Hospital
  • Lin Lisheng
    Department of Pediatric Cardiology, Ibaraki Children’s Hospital
  • Takahashi Miho
    Department of Child Health, Faculty of Medicine, University of Tsukuba
  • Murakami Takashi
    Department of Child Health, Faculty of Medicine, University of Tsukuba
  • Shiono Junko
    Department of Pediatric Cardiology, Ibaraki Children’s Hospital
  • Takada Hidetoshi
    Department of Child Health, Faculty of Medicine, University of Tsukuba

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  • 心炎を伴ったリウマチ熱6例の臨床経過と予後

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<p>Background: In recent years, acute rheumatic fever (ARF) has been considered an extremely rare condition in Japan, with an incidence of 5–10 cases annually. However, it should be recognized as a serious illness because some patients may develop heart failure (HF) if diagnosis and treatment are delayed.</p><p>Methods: The clinical course and prognoses of ARF with carditis in six patients (n＝3 women) diagnosed in our institutions from 1994 to 2018 were investigated by retrospectively reviewing medical records.</p><p>Results: The age at diagnosis was 3–13 (median: 8.5) years. The symptoms at onset were fever and arthralgia/arthritis in four, arthralgia/arthritis alone in one, and shortness of breath and fatigability due to HF in one patient. The duration from the initial presentation to the diagnosis of ARF ranged from 3 days to 4 years and 10 months (median: 11.5 days). None of the patients presented with major symptoms other than carditis and polyarthritis based on the revised Jones Criteria. Similar to valvulitis, aortic valve regurgitation (AR), mitral regurgitation (MR), and both AR and MR were observed in 5, 3, and 2 cases, respectively. The patients were treated with prednisolone and/or aspirin and antibiotics (provided as prophylaxis drugs). During follow-up (range: 1–15 [median: 9] years), MR almost disappeared; however, AR remained. Moreover, aortic valve replacement was required in two cases, and recurrence of ARF was not noted.</p><p>Conclusion: In this study, arthritis-related symptoms were more likely to be observed during the initial presentation, and the diagnosis of carditis was delayed, resulting in a critical clinical course in some cases. Patients with streptococcal infection-related polyarthritis should be screened for carditis by a pediatric cardiologist.</p>

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