Molecular mechanisms of cell shape changes that contribute to vertebrate neural tube closure
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説明
<jats:p>During early development of the central nervous system, the neuroepithelial cells undergo dynamic changes in shape, cumulative action of which cause the neural plate to bend mediolaterally to form the neural tube. The apicobasal elongation changes the cuboidal cells into columnar ones, whereas apical constriction minimizes the cell apices, causing them to adopt wedge‐like shapes. To achieve the morphological changes required for the formation of a hollow structure, these cellular changes must be controlled in time and space. To date, it is widely accepted that spatial and temporal changes of the cytoskeletal organization are fundamental to epithelial cell shape changes, and that noncetrosomal microtubules assembled along apicobasal axis and actin filaments and non‐muscle myosin II at the apical side are central machineries of cell elongation and apical constriction, respectively. Hence, especially in the last decade, intracellular mechanisms regulating these cytoskeletons have been extensively investigated at the molecular level. As a result, several actin‐binding proteins, Rho/<jats:styled-content style="fixed-case">ROCK</jats:styled-content> pathway, and cell–cell adhesion molecules have been proven to be the central regulators of apical constriction, while the regulatory mechanisms of cell elongation remain obscure. In this review, we first describe the distribution and role of cytoskeleton in cell shape changes during neural tube closure, and then summarize the current knowledge about the intracellular proteins that directly modulate the cytoskeletal organization and thus the neural tube closure.</jats:p>
収録刊行物
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- Development, growth & differentiation
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Development, growth & differentiation 54 (3), 266-276, 2012-04
Kobe : Japanese Society of Developmental Biologists ; 1969-2014
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詳細情報 詳細情報について
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- CRID
- 1520009407883130624
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- NII論文ID
- 10031136900
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- NII書誌ID
- AA00627804
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- ISSN
- 00121592
- 1440169X
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- NDL書誌ID
- 023607963
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- Web Site
- http://id.ndl.go.jp/bib/023607963
- https://ndlsearch.ndl.go.jp/books/R000000004-I023607963
- https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1440-169X.2012.01346.x
- https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1440-169X.2012.01346.x
- https://search.jamas.or.jp/link/ui/2013156037
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- 本文言語コード
- en
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- NDL 雑誌分類
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- ZR2(科学技術--生物学--生化学)
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- データソース種別
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- NDL
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