Characteristic metabolites of Hypericum plants : their chemical structures and biological activities

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<jats:title>Abstract</jats:title><jats:p>Plants belonging to the genus <jats:italic>Hypericum</jats:italic> (Hypericaceae) are recognized as an abundant source of natural products with interesting chemical structures and intriguing biological activities. In the course of our continuing study on constituents of <jats:italic>Hypericum</jats:italic> plants, aiming at searching natural product-based lead compounds for therapeutic agents, we have isolated more than 100 new characteristic metabolites classified as prenylated acylphloroglucinols, meroterpenes, ketides, dibenzo-1,4-dioxane derivatives, and xanthones including prenylated xanthones, phenylxanthones, and xanthonolignoids from 11 <jats:italic>Hypericum</jats:italic> plants and one <jats:italic>Triadenum</jats:italic> plant collected in Japan, China, and Uzbekistan or cultivated in Japan. This review summarizes their chemical structures and biological activities.</jats:p>

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