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Effects of testosterone on circadian rhythmicity in old mice
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Description
Serum testosterone concentration decreases with age in humans and rodents. Accordingly, old male mice show changes in locomotor activity rhythms: a lengthened free-running period and decreased activity levels among others. To investigate whether testosterone replacement improves the age-related decline in circadian rhythmicity, we examined the effects of testosterone on the circadian rhythms of wheel running activity in old male mice. Intact male C57BL/6J mice (18-22 months old) were subcutaneously implanted with silicone tubes packed with testosterone propionate (TP) or cholesterol. TP treatment significantly decreased the daily wheel running revolutions in a normal light/dark (LD) cycle and in constant darkness (DD), but did not affect the free-running period. The same experiment performed on young male gonadectomized mice (3-5 months old) demonstrated that TP treatment significantly increased activity levels in both LD and DD. These results suggest that testosterone replacement exacerbates the age-related decline in circadian rhythmicity.
Journal
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- The journal of physiological sciences
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The journal of physiological sciences 69 (5), 791-798, 2019-09
[Tokyo] : Physiological Society of Japan
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Details 詳細情報について
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- CRID
- 1520290883158168320
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- NII Article ID
- 40022006474
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- NII Book ID
- AA12129145
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- ISSN
- 18806546
- 18806562
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- NDL BIB ID
- 029852593
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- PubMed
- 31301005
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- Web Site
- http://id.ndl.go.jp/bib/029852593
- https://ndlsearch.ndl.go.jp/books/R000000004-I029852593
- http://link.springer.com/content/pdf/10.1007/s12576-019-00695-4.pdf
- http://link.springer.com/article/10.1007/s12576-019-00695-4/fulltext.html
- https://api.elsevier.com/content/article/PII:S1880654624004190?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S1880654624004190?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/2020232790
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- Text Lang
- en
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- Article Type
- journal article
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- NDL Source Classification
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- ZS8(科学技術--医学--解剖学・生理学・生化学)
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- Data Source
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- NDL Search
- Crossref
- CiNii Articles
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- OpenAIRE