Planar microfluidic system based on electrophoresis for detection of 130-nm magnetic labels for biosensing

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  • Planar microfluidic system based on electrophoresis for detection of 130 nm magnetic labels for biosensing
  • Special issue: Solid state devices and materials
  • Special issue Solid state devices and materials

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<jats:p> Superparamagnetic beads (SPBs) used as magnetic labels offer potential for the realization of high sensitivity and low cost biosensors for point of care treatment (POCT). For better biomolecular affinity and higher sensitivity, it is desirable to use sub-200-nm-diameter SPBs comparable in size to actual biomolecules. However, the detection of small concentrations of such SPBs by magnetoresistive devices is extremely challenging due to small magnetic response of SPBs. As a solution to these limitations, we describe a simple detecting procedure where the capture of micro-SPBs by immobilized nano-target SPBs due to self-assembly induced by an external magnetic field, which was monitored under an optical microscope. Here we describe biosensing system based on self-assembly of micro-SPBs by nanoSPBs targets using a system without external pumps, thereby enabling greater miniaturization and portability. </jats:p>

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