Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases
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説明
<jats:title>Abstract</jats:title> <jats:p>Conjugation of small molecular inhibitor with a site recognition peptide would generate highly potent peptide–drug conjugate inhibitors of protein kinases. A peptide selected by ribosome display with a tRNA carrying an inhibitor-conjugated amino acid exhibited up to 10- to 100-fold higher inhibitory effects towards different kinases than solely the inhibitor.</jats:p>
収録刊行物
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 89 (4), 444-446, 2016-04
Tokyo : Chemical Society of Japan
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詳細情報 詳細情報について
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- CRID
- 1520291855159800320
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- NII論文ID
- 130005144950
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- NII書誌ID
- AA00580132
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- ISSN
- 00092673
- 13480634
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- NDL書誌ID
- 027243266
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- 本文言語コード
- en
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- NDL 雑誌分類
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- ZP1(科学技術--化学・化学工業)
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- データソース種別
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- NDL
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