Nascent chain-mediated translation regulation in bacteria : translation arrest and intrinsic ribosome destabilization
Bibliographic Information
- Other Title
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- Multifaceted Protein World
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Abstract
<jats:title>Abstract</jats:title> <jats:p>Proteins that exsert physiological functions during being translated have been discovered from prokaryotes to eukaryotes. These proteins, also called regulatory nascent chains, are common in interacting co-translationally with the ribosomes to stall them. In most cases, such a translational arrest is induced or released in response to changes in the intracellular environment. Cells take advantage of such an environmental sensitivity as a sensor to feedback-regulate gene expression. Recent studies reveal that certain nascent chains could also destabilize the translating ribosomes, leading to stochastic premature translation termination. In this review, we introduce several examples of bacterial nascent chain-based mechanisms of translation regulation by which bacteria regulate cellular functions.</jats:p>
Journal
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- The journal of biochemistry
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The journal of biochemistry 173 (4), 227-236, 2023-04
Tokyo : Japanese Biochemical Society
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Details 詳細情報について
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- CRID
- 1520295879318377344
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- NII Book ID
- AA00694073
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- ISSN
- 0021924X
- 17562651
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- NDL BIB ID
- 032767030
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- Web Site
- http://id.ndl.go.jp/bib/032767030
- https://ndlsearch.ndl.go.jp/books/R000000004-I032767030
- https://academic.oup.com/jb/advance-article-pdf/doi/10.1093/jb/mvad007/49167370/mvad007.pdf
- https://academic.oup.com/jb/article-pdf/173/4/227/50484123/mvad007.pdf
- https://search.jamas.or.jp/link/ui/2024127493
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- Text Lang
- en
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- NDL Source Classification
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- ZR2(科学技術--生物学--生化学)
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- Data Source
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- NDL
- Crossref
- KAKEN