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ストレス社会が求める"くすり"の創薬研究--天然生薬からの新規抗うつ・抗不安様物質の発見

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  • ストレス シャカイ ガ モトメル クスリ ノ ソウヤク ケンキュウ テンネン ショウヤク カラノ シンキ コウウツ コウフアンヨウ ブッシツ ノ ハッケン
  • The drug development studies demanded on stressful society: discovery of novel antidepressive and anxiolytic substances from natural herb

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Abstract

Since antidepressive activity of imipramine was identified in 1950s, various antidepressants, including tricyclic or tetracyclic antidepressants, selective serotonin reuptake inhibitors and serotonin noradrenaline reputake inhibitors, have been developed, and the drug treatment of depressive disorder has made much progress. However, there are also a number of problems on the therapeutic efficacy as well as safety of existing antidepressants, and therefore, it should be necessary to develop more effective novel antidepressants. The leaves of Perilla frutescens Britton var. acuta Kudo (Perillae Herba) are commonly found in traditional oriental herbal medicines, which are primarily used to treat depression and onxiety-related disorders. We have recently identified rosmarinic acid as well as its major metabolite caffeic acid as novel antidepressive and/or anxiolytic-like substance from components within Perillae Herba. Also, neurochemical studies habe rebealed that neither rosmarinic acid or caffeic adic affects the uptake of monoamines and monoamine oxidase activity, which may underlie the therapeutic value of existing clinically effective antidepressants. Therefore, further studies on the mechanismis involved in the antidepressive- and/or anxiolytic-like properties of both substances could help to explain the patholosiology underlying depression and anxiety disorders, and pave the way for the development of new therapeutic drugs.

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