Inhibitory Effects of Chinese Quince (Chaenomeles sinensis) on Hyaluronidase and histamine Release from Rat Mast Cells

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  • カリン(Chaenomeles sinensis)果実のヒアルロニダーゼ阻害効果及びラット肥満細胞からのヒスタミン遊離阻害効果について
  • カリン Chaenomeles sinensis カジツ ノ ヒアルロニダーゼ ソガイ コウカ オヨビ ラット ヒマン サイボウ カラ ノ ヒスタミン ユウリ ソガイ コウカ ニ ツイテ
  • カリン(Chaenomeles sinensis)果実のヒアルロニダーゼ阻害効果及びラット肥満細胞からのヒスタミン遊離阻害効果について

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We assayed the anti-inflammatory effect of a 30% ethanol extract of Chinese quince (Chaenomeles sinensis) in vitro to show that it has an inhibitory effect on the histamine release from rat mast cells induced by compound 48/80, and on activation of hyaluronidase. Chromatographic separation of the extract gave five phenolic compounds and higher molecular weight polyphenols. Some of these compounds showed a potent inhibitory effect on the histamine release and on the hyaluronidase. The structure of the most active compound, a high molecular weight polyphenol, was analyzed by ^<13>C-NMR, thiol degradation reaction, and gel permeation chromatography (GPC) of its acetylated derivative.


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