A planarian orthopedia homolog is specifically expressed in the branch region of both the mature and regenerating brain

DOI Web Site Web Site Web Site PubMed 被引用文献39件 参考文献16件 オープンアクセス

書誌事項

タイトル別名
  • planarian orthopedia homolog is specifi

この論文をさがす

説明

<jats:p>To analyze the organization of planarian brain, a homolog of the homeobox‐containing gene <jats:italic>Orthopedia (Otp)</jats:italic> from planarian, <jats:italic>Djotp</jats:italic>, was isolated. The homeodomain of <jats:italic>Djotp</jats:italic> differs from mouse <jats:italic>Otp</jats:italic> by only two amino acids. This conservation extends to include a 12 amino acid motif downstream of the homeodomain. Whole mount <jats:italic>in situ</jats:italic> hybridization studies indicated that <jats:italic>Djotp</jats:italic> is specifically expressed in the branch structures of the normal planarian adult brain. During regeneration, <jats:italic>Djotp</jats:italic> is expressed in the presumptive branch region prior to branch formation. These observations implicate a role for <jats:italic>Djotp</jats:italic> in establishing and maintaining the identity of the planarian brain branch region. The results suggest that recruitment of <jats:italic>Otp</jats:italic> for its role in brain pattern formation occurred very early in evolution.</jats:p>

収録刊行物

被引用文献 (39)*注記

もっと見る

参考文献 (16)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ